Cardiorespiratory Fitness Level Alters Blood Pressure Responses Induced By Histamine H1- And H2-receptor Blockade During Dynamic Exercise

INTRODUCTION: Epidemiological studies have reported that greater cardiorespiratory fitness (CRF) is associated with lower blood pressure (BP). Histamine receptor-mediated peripheral vasodilation contributes to post-exercise hypotension and lowing exercising BP responses. Previously, our laboratory found overactive responses exercise were induced by the inability of histamine receptors in individuals prehypertension. However, it still unknown CRF can impact elicited receptors. PURPOSE: This study was assess whether aerobic effective lowering excessive blockade METHODS: In twelve male female subjects (6 high 6 low CRF), we examined effects H1- H2- receptor blockades on heart rate (HR), stroke volume (SV), cardiac output (CO), systolic (SBP), diastolic (DBP), mean arterial (MAP), total resistance (TPR) at workloads corresponding 40% 60% VO2peak during cycling exercise. RESULTS: Our indicated compared group, changes MAP from baselines higher group before each workload (40%: D14±2 vs. 8±1 mmHg; 60%: D21±3 15±2 mmHg). The response substantially D18±2 11±1 D29±3 19±2 CONCLUSIONS: suggests an improvement likely reduces exaggerated due pathological conditions such as prehypertension hypertension.